It is advised not to take alcohol while on Zoloft medication as it can make you feel drowsier. One drink can have an effect of two. For example, it will enhance the severity of side effects like drowsiness, slow reflexes etc. these effects might take place immediately or after sometime.

Do not take liquid form of Zoloft if you are taking Disulfiarm (Antabuse). It is learnt that liquid Zoloft can contain alcohol which can cause serious side effects with Disulfram.

If you usually experience the feeling of tiredness, depression after drinking, then these feelings might get enhanced if you are taking zoloft with alcohol.

Alcohol being a central nervous system depressant and zoloft producing sedative effects can result in lowered heart rate and blood pressure changes. You might increase the risk of enhancing these effects if you consume larger quantity of alcohol.

Headaches and Sexual Dysfunction are possible side effects related with the combination of alcohol and antidepressant medications like zoloft.